What do I do now?

Here are some videos to help you understand all this genetic stuff!                       Here is some more info on specific genetic markers.

Genes, DNA and Chromosomes Explained

What is DNA?

Understanding Mutations Part 1 Basic

Understanding Mutations Part 2

GSTP Mutation and Glutathione Conjugation

You can change your genes!

A Case for Breastfeeding!

There are many documents in the client section to help you know what things are such as Vitamin E Foods, Methyl Donors and what are the 3 Phases of Detoxification. (Client Support Page)  (Partner Support Page)

If you have not joined the MTHFR~ Hope for Change do so.  This group has many resources and videos to help you understand more. 

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Specific Genetic Markers

CYP Mutations:

​Gene Function:
This gene is responsible for detoxing about 20% of prescription drugs and most steroid hormones, and Phase I detox and E2 to 2- hydroxyestradiol.

Possible Problems are: 
Possible ultra metabolizer, Enzyme reaction, reduced enzyme function, slow to metabolize caffeine, and is the main liver pathway.

Possible Supplement(s) that help:  
DIM or Indole 3 Carbinol, consume higher amts. of broccoli, Cabbage, Brussel Sprouts/ add DIM, Glucarate, NAC, Cardamom (spice) Sulforaphane (resveratrol/broccoli) 
 
(See GSTP Mutation if you are to avoid Vitamin E foods)

Things to Avoid:
Curcumin, Cumin, Tumeric, Grapefruit, Quercetin, Bioperine, and Milk thistle

(Try Boswellia or Mullein or Bilberry instead)

GSTP Mutation:

Gene Function:
​This gene is responsible for Conjugation of toxins to glutathione.  See the Glutathione Video to understand this more.

​Possible Problems are:
Can lead to an increase in inflammatory interleukin-6 (IL-6) upon supplementing Vitamin E in alpha-tocopherol form which is the most common in our diets.

Possible Supplement(s) that help: 
NAC or N-Acetyl Cysteine and Whey protein

Things to Avoid:
​Vitamin E Foods
​see the chart in Client Support Section (Partner Support Page)
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Nat2 Mutations

Gene Function:
Encode and metabolize drugs (legal and illegal) and carcinogens (cancer causing).

Possible Problems: 
Fast/decresed/slow metablozier and/or activity
​
Possible Supplement(s) that help:
NAC or N-Acetyl Cysteine, Vitamins B2, 3,5 and Molybdenum
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​Things to Avoid:

COMT

Gene Function:
Breakdown hormones, Phase II detoxing (liver), breakdown hydroxy-estrogens
​
Possible Problems:
​Amino acid sequence, lower expression of gene, less breakdown of hormones

Possible Supplement(s) that help:
Hydroxy B-12 or Hydrocabolomin

Things to Avoid:
Methyl Donors, Methyl B-12

MAO-A 

​Gene Function:
 This gene oxidizes or combines with oxygen and affects serotonin, dopamine, epinephrine, and epinephrine.

Possible Problems:
Less oxidization and/or breakdown and lower expression of the gene.
 
Possible Supplement(s)that help:
Various types of progesterone based on the specific person (TBD)
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Things to Avoid:
Curcumin, Cumin, and sex hormones

CBS Mutations

 Gene Function:
Adds l-serine to homocysteine to produce l-cystathionine.  Basically enzyme acts in a chemical pathway and is responsible for using vitamin B6 to convert building block of proteins (amino acid).

Possible Problems:
High Taurine, Ammonia and Sulfate levels, decrease in Glutathione Synthesis

Possible Supplement(s)that help:
Arginine, Manganese, Molybdenum, Zinc, Vitamin B6 (P5P form only in some people) and CoQ10 (ubiqinol form)

Things to Avoid:
Methyl Donors, Vitamin B6 (P5P form is ok), Taurine, Sulfates and BCAA

ACAT1

Gene Function:
Forms cholesterol esters (hydrophobic (tending to repel or fail to mix with water)) from cholesterol

Possible Problems:
Beta-ketothiolase deficiency (BKT) in which newborns cannot effectively process a protein building block (amino acid) called isoleucine (tics, tremours, and twitching)

Possible Supplement(s)that help:
Probiotics, Vitamin B12 (see other mutations for type) and best on a low fat diet and exercise.  

Things to Avoid:
Cholesterol (click here for more cholesterol info)

More Mutations coming soon